Some applications save files continuously or at small intervals. These applications are not suitable to save files directly on the CacheDrive shares, because they will increase the storage usage and consume the Internet bandwidth unnecessarily. 

For example, OneNote continuously updates files while editing. There is no mechanism to set autosave intervals in OneNote. In this case, it is more efficient to store OneNote files in Office 365. 

Another app that constantly autosaves is Adobe InDesign. We recommend editing the InDesign file on the client machine and copying the file over for safekeeping and sharing.